Truthbutter

Category Archives: Ibd And Gut Health

Can L-Glutamine Cause Brain Fog? {Monday Musings}

Welcome to Monday Musings! I don’t expect this to be a weekly thing, but I wanted a nifty little label to slap on posts where I’m basically just thinking out loud. Wouldn’t want to delude anyone into thinking I have all the answers, now would I?
Thanks for being here!

L-glutamine, once a lowly amino acid vying for attention among 19 siblings, has become a darling of functional medicine for its role in gut health and intestinal permeability. L-glutamine is an important fuel source for enterocytes, which are the cells lining the intestines, and there’s pretty solid evidence that L-glutamine can help strengthen the intestinal barrier.

That all sounds fantastic, right? I sure thought so, and I supplemented accordingly, on and off, for several years. But recently, some self-experimentation has led me to suspect L-glutamine of being a contributor to some pretty intense brain fog and other mental symptoms I’ve been experiencing. L-glutamine was low on my list of suspects, because I had such positive expectations of it, so it took me a while to notice an association. But the timing was there, so I decided to investigate. Read more →

POW: Therapeutic Manipulation of the Microbiome in IBD

Hellooo, friends, and welcome to the first weekly installment of Paper of the Week (POW)! This delightful new feature of my blog is where I read a paper that I want to read, and then I tell you about it. That way you learn something (theoretically), and I actually remember what I read (theoretically).

This Week’s Paper

Title: Therapeutic Manipulation of the Microbiome in IBD: Current Results and Future Approaches

Authors: Jonathan Hansen and Balfour Sartor (gastroenterologists and researchers at UNC aka MY SCHOOL #represent)

Year: 2015

Type: Review paper

Abstract (partial): 

Despite recent major strides in our understanding of the genetic and microbial influences that contribute to the development of the inflammatory bowel diseases (IBDs), their etiology continues to be enigmatic. Results from experiments in animal models of IBDs overwhelmingly support a causal role of the microbiota in these diseases, though whether such a cause-effect relationship exists in human IBDs is still uncertain. Therefore, virtually all currently approved and most often prescribed treatments for IBDs are directed toward the over-active immune response in these diseases rather than the intestinal bacteria. Nevertheless, there is an important need for non-immunosuppressive therapies that may present a more favorable risk-benefit profile such as those that selectively target the disruptions in gut microbiota that accompany IBDs. This need has led to clinical trials of various microbial-directed therapies including fecal microbial transplant, antibiotics, probiotics, and prebiotics. Unfortunately, these published studies, many of which are small, have generally failed to demonstrate a consistent benefit of these agents in IBDs, thus leading to slow acceptance of microbe-focused treatments for these conditions.”

Let’s go!

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